National Pathology

Diagnostic Laboratory

The Diagnostic Laboratory is a specialised unit within the Midlands State University National Pathology Research and Diagnostic Centre. The laboratory is equipped with the latest state-of-the-art technology and staffed with young, energetic, highly skilled, and experienced scientists and technicians who are committed to providing accurate and timely diagnoses.

Our laboratory offers a wide range of diagnostic tests and services.  These are spread across the following departments:

  1. Histology
  2. Hematology
  3. Microbiology
  4. Molecular diagnostics 
  5. Biochemistry
  6. Immunochemistry
  7. Serology
Histology

This department involves the anatomical study of structural and cellular changes in tissues under a microscope for the diagnosis of cancers. It basically entails the following:

Examination of sampled tissues/organs/Cells under the microscope.

Categorization of malignant tumor types (e.g. carcinoma, lymphoma, germ cell, sarcoma, and melanoma)

Determining the site of origin for metastatic tumors.

Sub-classification of tumors in various organ systems

-Cytology, Immunohistochemistry (IHC), and Frozen Sectioning are specialized subsections of the Histology department involving the examination of cellular components (e.g. PAP smear), specific protein biomarkers in tissues (e.g. INI1, STAT6), and rapid examination of cryo-frozen biopsies, respectively.

Hematology

Haematology is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to blood

Microbiology

Microbiology is the scientific study of microorganisms, or microbes, which are living forms that are usually too small to be seen with the naked eye. Microorganisms include different types of cells, such as unicellular, multicellular, or acellular, and different groups, such as bacteria, archaea, fungi, protozoa, algae, and viruses.

Our laboratory provides a comprehensive range of microbiology services, including microscopy, culture, and sensitivity testing for urine, wound/ear/throat/vaginal swabs, stool, CSF, blood, and aspirates

Medical Examinations (for Food Handlers/Mineworkers/ Entry level exams) – these entail a physical and physiological examination, which is a standard health procedure to assess vital signs and other physiological variables such as fitness levels, physical capacity, and psychological soundness. It is a process of inspecting or testing for evidence of disease or abnormality in workers and certifying them fit for service. (e.g. urinalysis, rectal swabs, x-rays, audiometry, etc.)

The Diagnostic Laboratory also puts focus on the prevention and surveillance of infectious diseases by participating in a variety of programs like:

-The Malaria Program

-Food/Water-Borne disease outbreaks (e.g. Typhoid, Cholera)

-AMR monitoring and Surveillance

-TB/HIV monitoring and Surveillance

Molecular Diagnostics

We offer a broad range of molecular diagnostic tests, including polymerase chain reaction (PCR) testing, gene sequencing, and genotyping.

Our laboratory is equipped with the latest technology, including automated analysers and high-throughput sequencing platforms, which allow us to process samples quickly and accurately. Our scientists and technicians are highly trained and experienced, and we adhere to strict quality control and assurance protocols to ensure the accuracy and reliability of our results.

Examples include: TB diagnosis and TB resistance, HIV Viral load and HIV drug resistance, DNA Paternity testing, Quantitative TR-PCR assays, Molecular Oncology, Molecular Microbiology, and Molecular Genetics

Biochemistry

Chemistry involves the biochemical investigation of bodily fluids such as blood, urine, and cerebrospinal fluid.  By discovering how and where the body’s chemistry has changed, diseases can be diagnosed and monitored. Chemistry assays are one of the basic tests to assess any change in a person’s metabolism. We have high-end and high-throughput equipment with a very broad spectrum of tests.

Examples include: Toxicology (e.g. Therapeutic drug monitoring, Drug abuse residues in urine), kidney function tests, Thyroid Function Tests (e.g. T3, T4, Thyroxine), Lipid Profiles, Liver function tests (e.g. AST, ALP, TP, DBil, TBil, AST), Glucose/Glycosylated Hemoglobin for the Diagnosis and monitoring of Diabetes, Bone Profile analysis, Specific Proteins e.g. Albumin, AFP, Insulin etc

Immunochemistry

Immunochemistry is the study of the chemistry of the immune system. This involves the study of the properties, functions, interactions, and production of the chemical components of the immune system, such as antibodies/immunoglobulins, toxins, epitopes of proteins like CD4, antitoxins, cytokines/chemokines, and antigens. The body reacts to any physiologic change by eliciting an immune response. To this end, the Immunochemistry department focuses on identifying markers of disease by identifying immune system changes.

The laboratory has broad-spectrum analyzers capable of diagnosing a host of diseases and conditions

Examples include: Cancer Markers (PSA, Ca19.9, Ca125 for the Diagnosis and monitoring of prostate cancer, Breast Cancer, and Liver cancer etc.), Vitamin B12 AND Folate, Male and Female fertility hormones (FSH, Estrogen, LH, Progesterone, Prolactin and Testosterone), Thyroid function test, Cardiac Biomarkers (Troponin, CK, CKMB)

Serology

This department focuses on diagnosing diseases by the principle of antibody-antigen interactions. In response to an infection, the body elicits an immune response which involves the release of antibodies to target a particular infecting organism, self or non-self. Rapid kits are used for rapid diagnosis of infections

Examples include: RPR for Syphilis, HIV, TB LAM, CRP, CrAg, ASOT, Chlamydia test, CRP, RF, Herpes Screen, Hepatitis Screen, Pregnancy test, HSV 1 /2, Widal Test, H Pylori, COVID-19, Malaria RDT, Drug abuse residues in urine

Quality Management Protocols

At the Midlands State University National Pathology Research and Diagnostic Centre, we are committed to providing the highest quality diagnostic services to our patients. We understand that accurate and timely diagnoses are essential for effective treatment, and we strive to provide our Clinicians with the information they need to make informed decisions. The Diagnostic Laboratory abides by the dictates of the ISO 15189:2022: MEDICAL LABORATORIES – REQUIREMENTS FOR QUALITY AND COMPETENCE. The laboratory also ensures quality protocols by performing Internal Quality Controls, Inter Laboratory Comparisons and also participates in Proficiency testing schemes for External Quality Assurance.

The Laboratory performs periodic Competency Assessment training to ensure that the staff is up to date with the dynamics of diagnostic testing.

Verification of equipment performance is done regularly to ensure that all equipment is performing to expectations and producing accurate results.

If you have any questions about our diagnostic laboratory or the services we offer, please do not hesitate to contact us. We look forward to working with you to ensure the health and well-being of our communities.

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